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Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. After 2 weeks of completion of induction therapy, patients receive chemoradiation.
Drugs used in chemotherapy, such as cisplatin, etoposide, paclitaxel, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. ARM III (induction therapy): Patients receive crizotinib PO twice daily (BID) for up to 12 weeks.
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This randomized phase II trial studies how well erlotinib hydrochloride or crizotinib with chemoradiation therapy works in treating patients with stage III non-small cell lung cancer. ARM I (induction therapy): Patients receive erlotinib hydrochloride orally (PO) once daily (QD) for up to 12 weeks.
Radiation therapy uses high energy x rays to kill tumor cells. Patients who have had no response (partial or complete) after 6 weeks undergo concurrent chemoradiation therapy immediately.
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